The Institute for Imaging Science and Computational Modelling (ICM) (icm.charite.de) is part of Charité university hospital in Berlin, Germany. Consisting of a team of engineers and clinicians, we focus on computational modeling of cardiovascular diseases. The aim is to employ established as well as novel engineering and modeling techniques to investigate hemodynamic pathologies of several cardiovascular diseases, such as heart valve insufficiencies or aortic stenosis. A major part of this research aims at developing and validating modeling tools to support the clinical decision making process. This not only implies novel approaches to non-invasively quantify clinical parameters, but also methods to predict the hemodynamic outcome of interventions such as stenting or valve replacement.
Our team is investigating the feasibility of Computational Fluid Dynamics (CFD) to accurately predict aortic hemodynamics before and after the treatment. Over the years, we developed a comprehensive and efficient workflow to perform accurate patient specific CFD simulations based in medical imaging data. Combined with our large clinical database, our interdisciplinary work forms the basis of the ArtiCardio project, providing patient-specific anatomical and hemodynamic data allowing to cover a broad variability of pathological situations and, together with the flow solution, data to train the machine learning framework.